Asymptotic time dependence in the fractal pharmacokinetics of a two-compartment model
Authors:
- Przemysław Chełminiak,
- R.E. Marsh,
- J.A. Tuszyński,
- J.M. Dixon,
- K.J.E. Vos
Abstract
We further investigate, both analytically and numerically, the properties of the fractal two-compartment model introduced by Fuite [J. Fuite, R. Marsh, and J. Tuszynski, Phys. Rev. E 66, 021904 (2002)]. Specifically, we look at the effects of the fractal exponent of the elimination rate coefficient on the long-time behavior of the pharmacokinetic clearance tail. For small exponent values, the tail exhibits exponential behavior, while for larger values, there is a transition to a power law. The theory is applied to seven data sets simulating drugs taken from the pharmacological literature. © 2005 The American Physical Society.
- Record ID
- UAM0a889d1efd194c98a47c0cb4e31b3b3a
- Author
- Journal series
- Physical Review E, ISSN 1539-3755
- Issue year
- 2005
- Vol
- 72
- ASJC Classification
- ; ;
- DOI
- DOI:10.1103/PhysRevE.72.031903 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 0
- Score source
- journalList
- Publication indicators
- = 11; = 10; : 2014 = 1.123; : 2006 (2 years) = 2.438 - 2007 (5 years) =2.484
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAM0a889d1efd194c98a47c0cb4e31b3b3a/
- URN
urn:amu-prod:UAM0a889d1efd194c98a47c0cb4e31b3b3a
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.