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Biological evaluation of an imidazole-fused 1,3,5-triazepinone nucleoside and its photochemical generation via a 6-azidopurine modified oligonucleotide
Authors:
- Krzysztof Komodziński,
- Jolanta Lepczyńska,
- Piotr Ruszkowski,
- Jan Milecki,
- Bohdan Skalski
Abstract
The antitumor effects of a novel imidazole-fused 1,3,5-triazepinone nucleoside on KB, MCF-7, and HeLa cell lines were studied via a sulforhodamine B (SRB) colorimetric assay. The results show that the growth of three cancer cell lines studied was significantly inhibited. A method for incorporation of this novel 'fat' nucleoside into oligodeoxynucleotides, based on photochemical transformation of 6-azidopurine has been developed. © 2013 Elsevier Ltd. All rights reserved.
- Record ID
- UAM2bf6f03e320443028591d82d7af64fc7
- Author
- Journal series
- Tetrahedron Letters, ISSN 0040-4039
- Issue year
- 2013
- Vol
- 54
- Pages
- 3781-3784
- ASJC Classification
- ; ;
- DOI
- DOI:10.1016/j.tetlet.2013.05.051 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 25
- Score source
- journalList
- Score
- Publication indicators
- = 6; = 7; : 2014 = 0.796; : 2013 (2 years) = 2.391 - 2013 (5 years) =2.295
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAM2bf6f03e320443028591d82d7af64fc7/
- URN
urn:amu-prod:UAM2bf6f03e320443028591d82d7af64fc7
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.