Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
Authors:
- Marta Fik-Jaskółka,
- Izabela Maria Pospieszna-Markiewicz,
- Giovanni N. Roviello,
- Maciej Kubicki,
- Wanda Radecka-Paryzek,
- Violetta Patroniak
Abstract
Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine (LaPA complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K+ solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies. Moreover, LaPA induced structural changes in the Tel26 structure in a K+-deprived solution, suggesting that it may also lead to conformational changes in “non-G4” telomeric DNA.
- Record ID
- UAM35b2dda5a0c1444a8afd800fe9f48d4b
- Author
- Journal series
- Inorganic Chemistry, ISSN 0020-1669, e-ISSN 1520-510X
- Issue year
- 2021
- Vol
- 60
- No
- 4
- Pages
- 2122–2126
- ASJC Classification
- ;
- DOI
- DOI:10.1021/acs.inorgchem.0c03260 Opening in a new tab
- URL
- https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c03260 Opening in a new tab
- Language
- (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- = 140.0, 17-05-2022, ArticleFromJournal
- Publication indicators
- = 0; : 2018 = 1.092; : 2019 (2 years) = 4.825 - 2019 (5 years) =4.501
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAM35b2dda5a0c1444a8afd800fe9f48d4b/
- URN
urn:amu-prod:UAM35b2dda5a0c1444a8afd800fe9f48d4b
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.