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Complex of rutin with β-cyclodextrin as potential delivery system

Authors:

  • Magdalena Paczkowska,
  • Mikołaj Mizera,
  • Hanna Piotrowska,
  • Daria Szymanowska-Powałowska,
  • Kornelia Lewandowska,
  • Joanna Gościańska,
  • Robert Andrzej Pietrzak,
  • Waldemar Bednarski,
  • Zbigniew Majka,
  • Judyta Cielecka-Piontek

Abstract

This study aimed to obtain and characterize an RU-β-CD complex in the context of investigating the possibility of changes in the solubility, stability, antioxidative and microbiological activity as well as permeability of complexated rutin as against its free form. The formation of the RU-β-CD complex via a co-grinding technique was confirmed by using DSC, SEM, FT-IR and Raman spectroscopy, and its geometry was assessed through molecular modeling. It was found that the stability and solubility of the so-obtained complex were greater compared to the free form; however, a slight decrease was observed inits antibacterial potency. An examination of changes in the EPR spectra of thecomplex excluded any reducing effect of complexation on the antioxidative activity of rutin. Considering the prospect of preformulation studies involving RU-β-CD complexes, of significance is also the observed possibility of prolongedly releasing rutin from the complex at a constant level over along period of 20 h, and the fact that twice as much complexated rutin was able topermeate compared to its free form.

Metrics

Record ID
UAM46f3e54e8a074f1598a0587c23d184cb
Author
Magdalena Paczkowska Magdalena Paczkowska,, External affiliation of publication: Poznan University of Medical Sciences, Mikołaj Mizera Mikołaj Mizera,, External affiliation of publication: Poznan University of Medical Sciences, Hanna Piotrowska Hanna Piotrowska,, External affiliation of publication: Poznan University of Medical Sciences, Daria Szymanowska-Powałowska Daria Szymanowska-Powałowska,, External affiliation of publication: Uniwersytet Przyrodniczy w Poznaniu, Kornelia Lewandowska Kornelia Lewandowska,, External affiliation of publication: Institute of Molecular Physics of the Polish Academy of Sciences, Joanna Gościańska Joanna Gościańska,, , Robert Andrzej Pietrzak Robert Andrzej Pietrzak,, , Waldemar Bednarski Waldemar Bednarski,, External affiliation of publication: Institute of Molecular Physics of the Polish Academy of Sciences, Zbigniew Majka Zbigniew Majka,, External affiliation of publication: N7 Mobile Sp. Z O.o., Judyta Cielecka-Piontek Judyta Cielecka-Piontek,, External affiliation of publication: Poznan University of Medical Sciences
Journal series
Plos One, ISSN 1932-6203
Issue year
2015
Vol
10
ASJC Classification
1100 General Agricultural and Biological Sciences; 1300 General Biochemistry, Genetics and Molecular Biology; 2700 General Medicine
DOI
DOI:10.1371/journal.pone.0120858 opening in a new tab
Language
en English
Score (nominal)
40
Score source
journalList
Score
Publication indicators
Scopus Citations = 13.000; Scopus SNIP: 2015 = 1.136; WoS Impact Factor: 2015 = 3.057 (2) - 2015=3.535 (5)

Cite

Uniform Resource Identifier
https://researchportal.amu.edu.pl/info/article/UAM46f3e54e8a074f1598a0587c23d184cb/

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perishopening in a new tab system.

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