Insulin-like growth factor and interacting proteins

Authors:

• Aleksandra Obrepalska-Steplowska,
• Julia Łucja Durzyńska,
• Anna Goździcka-Józefiak

Abstract

Insulin-like growth factor - IGF-I is a small, 70 aminoacid mitogenic peptide, contributing to processes of growing, cancerogenesis, apoptosis, wound healing and many others. It constitutes so called 'somatotropic axis GH-IGF', composed of many other components. This axis is responsible for regulation of metabolic processes, and its proper functioning conditions organism's homeostasis. Presented work describes concise review of publications concerning IGF-I structure, function, expression and proteins affecting its activity, synthesis and circulation.