Synthesis, Structural Features, Cytotoxicity, and Magnetic Properties of Colloidal Ferrite Spinel Co1-x Nix Fe2 O4 (0.1 ≤ x ≤ 0.9) Nanoparticles
Authors:
- Robert Pązik,
- Aleksander Zięcina,
- Emilia Zachanowicz,
- Malgorzata Małecka,
- Blazej Poźniak,
- Julia Miller,
- Zbigniew ͆niadecki,
- Natalia Urszula Pierunek,
- Bogdan Idzikowski,
- Lucyna Mrówczyńska,
- Anna Ewa Ekner-Grzyb,
- Rafal J. Wiglusz
Abstract
Colloidal ferrite spinel nanoparticles (CoxNi1-xFe2O4) were prepared by a microwave-stimulated Bradley technique under nonhydrolytic conditions. The effect of Ni2+ doping on the structural properties was studied by powder XRD. The particle size, hydrodynamic size, and morphology were evaluated by transmission electron microscopy (TEM) and dynamic light scattering (DLS), which showed mean crystallite sizes of ca. 10 and 60 nm for powder and colloidal suspensions of CoxNi1-xFe2O4, respectively. The cytotoxicity of the nanoparticles was tested against murine macrophages J774.E, osteosarcoma D17 cells, and human red blood cells (RBCs). The adsorption of bovine serum albumin (BSA) was studied, and the BSA showed a high affinity for the surface of the nanoparticles. The CoxNi1-xFe2O4 nanoparticles in colloidal suspension showed dose-dependent cytotoxicity against all of the studied cell lines, and less harmful effects were observed against RBCs at concentrations of up to 0.1 mg/mL. The cytotoxicity towards the D17 and J774.E cells suggests that internalization by the living cells seems to be the key step to elicit the toxic response. Thus, the cytotoxicity of the particles under investigation seems to be cell-type-dependent and not uniform. The CoxNi1-xFe2O4 colloids exhibited superparamagnetic behavior with blocking temperatures (TB) below 300 K. The magnetic characteristics are well preserved in colloidal form and are similar to those of the powdered ferrites.
- Record ID
- UAM7adce9a3b6d946088bb8414b72dcdbdb
- Author
- Journal series
- European Journal of Inorganic Chemistry, [Chemische Berichte], ISSN 1434-1948, e-ISSN 1099-0682, [0009-2940]
- Issue year
- 2015
- Vol
- 2015
- Pages
- 4750-4760
- ASJC Classification
- DOI
- DOI:10.1002/ejic.201500668 opening in a new tab
- Language
- en English
- Score (nominal)
- 35
- Score source
- journalList
- Score
- Publication indicators
- = 8.000; : 2015 = 0.745; : 2015 = 2.686 (2) - 2015=2.680 (5)
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAM7adce9a3b6d946088bb8414b72dcdbdb/
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perishopening in a new tab system.
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