Record ID

UAM890b473fb8ba4fdcbb5a0810a93fee85

Author

Monika Szefczyk Monika Szefczyk,, Undefined Affiliation

Natalia Szulc Natalia Szulc,, Undefined Affiliation

Marlena Gąsior-Głogowska Marlena Gąsior-Głogowska,, Undefined Affiliation

Anna Modrak-Wójcik Anna Modrak-Wójcik,, Undefined Affiliation

Agnieszka Bzowska Agnieszka Bzowska,, Undefined Affiliation

Wojciech Majstrzyk Wojciech Majstrzyk,, Undefined Affiliation

Michał Taube Michał Taube,, Department of Biomedical Physics [nowa struktura organizacyjna] (SNŚ/WyF/JBWF)Szkoła Nauk Ścisłych [nowa struktura organizacyjna] (SNŚ)

Maciej Kozak Maciej Kozak,, Department of Biomedical Physics [nowa struktura organizacyjna] (SNŚ/WyF/JBWF)Szkoła Nauk Ścisłych [nowa struktura organizacyjna] (SNŚ)

Teodor Gotszalk Teodor Gotszalk,, Undefined Affiliation

Ewa Rudzińska-Szostak Ewa Rudzińska-Szostak,, Undefined Affiliation

Łukasz Berlicki Łukasz Berlicki,, Undefined Affiliation

et al.

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Journal series

Nanoscale, ISSN 2040-3364, e-ISSN 2040-3372

Issue year

2021

ASJC Classification

2500 General Materials Science

Abstract in original language

The rational design of novel self-assembled nanomaterials based on peptides remains a great challenge in modern chemistry. A hierarchical approach for the construction of nanofibrils based on α,β-peptide foldamers is proposed. The incorporation of a helix-promoting trans-(1S,2S)-2-aminocyclopentanecarboxylic acid residue in the outer positions of the model coiled-coil peptide led to its increased conformational stability, which was established consistently by the results of CD, NMR and FT-IR spectroscopy. The designed oligomerization state in the solution of the studied peptides was confirmed using analytical ultracentrifugation. Moreover, the cyclopentane side chain allowed additional interactions between coiled-coil-like structures to direct the self-assembly process towards the formation of well-defined nanofibrils, as observed using AFM and TEM techniques.

DOI

DOI:10.1039/d0nr04313c Opening in a new tab

Language

(en) English

Score (nominal)

140

Score source

journalList

Score

Ministerial score = 140.0, 14-05-2022, ArticleFromJournal

Publication indicators

WoS Citations = 3; Scopus SNIP: 2017 = 1.442; WoS Impact Factor: 2019 (2 years) = 6.895 - 2019 (5 years) =7.315

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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.