Determination of hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS
Authors:
- Anna Olejnik,
- Izabela Justyna Nowak,
- Krystian Eitner,
- Grzegorz Marek Schroeder
Abstract
The hexapeptide ALA-ASP-LEU-LYS-PRO-THR is currently widely used as an active ingredient in commercially available creams. Therefore, the proper analytical procedure to detect this compound is a very important issue. This paper presents the determination of the hexapeptide in solution and in cosmetic formulations by matrix assisted laser desorption ionisation mass spectrometry. We developed a procedure for the selective binding of the low molecular weight peptide by using a two-component matrix which enabled us to characterize the hexapeptide directly without any initial processing. Furthermore, the extensive computer simulations were carried out to assist in this analysis of the MS spectra. © 2012 The Author(s).
- Record ID
- UAM8df5f55858f74fa692a8c9c54ac938eb
- Author
- Journal series
- International Journal of Peptide Research and Therapeutics, ISSN 1573-3149
- Issue year
- 2013
- Vol
- 19
- Pages
- 217-224
- ASJC Classification
- ; ; ; ;
- DOI
- DOI:10.1007/s10989-012-9334-8 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 15
- Score source
- journalList
- Score
- Publication indicators
- = 4; = 6; = 6; : 2013 = 0.567; : 2013 (2 years) = 0.825 - 2013 (5 years) =0.937
- Citation count
- 6
Share
- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAM8df5f55858f74fa692a8c9c54ac938eb/
- URN
urn:amu-prod:UAM8df5f55858f74fa692a8c9c54ac938eb
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.