Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus
Authors:
- Sakineh Alizadeh Golsorkhdan,
- Mahdi Eskandarian Boroujeni,
- Abbas Aliaghaei,
- Mohammad Amin Abdollahifar,
- Afshar Ramezanpour,
- Reza Nejatbakhsh,
- Iraj Jafar Anarkooli,
- Elahe Barfi,
- Mohammad Javad Fridoni
Abstract
Methamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of short term, long term and spatial memory. Herein, we explored the changes in behavior, synaptic transmission and hippocampal volume along with gliosis following METH treatment. Besides, using genome-wide expression profiling, we applied a pathway-based approach to detect significantly dysregulated signaling pathways. In this regard, we found that METH administration interrupts spatial memory and long term potentiation (LTP). Additionally, stereological analysis revealed a significant alteration in hippocampal volume along with increased gliosis upon METH treatment. We also identified several signaling cascades chiefly related to synaptic transmission which were considerably interrupted in the hippocampus of METH-treated rats. Taken together, our data suggests a potential link between behavioral disruptions and dysregulated signaling pathways. © 2019 Elsevier B.V.
- Record ID
- UAMb869909dcd624a658483ab96cde776bf
- Author
- Journal series
- Behavioural Brain Research, ISSN 0166-4328, e-ISSN 1872-7549
- Issue year
- 2020
- Vol
- 379
- Pages
- 1-8
- Article number
- 112300
- Keywords in English
- Hippocampus; Methamphetamine; Neurotransmission; RNA-seq; methamphetamine; RNA, adult; animal experiment; animal tissue; Article; astrocytosis; behavior disorder; brain size; controlled study; gene expression profiling; gene ontology; gliosis; hippocampus; immunohistochemistry; long term potentiation; male; memory disorder; nonhuman; passive avoidance test; priority journal; rat; RNA extraction; RNA sequence; signal transduction; spatial memory; stereology; synaptic transmission; transcriptomics; Y-maze test
- ASJC Classification
- DOI
- DOI:10.1016/j.bbr.2019.112300 Opening in a new tab
- URL
- https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075353541&doi=10.1016%2fj.bbr.2019.112300&partnerID=40&md5=66778456cae6665b8d0bfd7116abd708 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 100
- Score source
- journalList
- Score
- = 100.0, 13-01-2022, ArticleFromJournal
- Publication indicators
- = 13; : 2018 = 0.895; : 2019 (2 years) = 2.977 - 2019 (5 years) =3.115
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMb869909dcd624a658483ab96cde776bf/
- URN
urn:amu-prod:UAMb869909dcd624a658483ab96cde776bf
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.