Advances in the Evolutionary Understanding of MHC Polymorphism
Authors:
- Jacek Radwan,
- Wiesław Babik,
- Jim Kaufman,
- Tobias Lenz,
- Jamie Winternitz
Abstract
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies. Recent studies provide evidence that these features may arise due to pathogens evolving ways to evade immune response guided by the locally common MHC alleles. However, complexities of selection on MHC genes are simultaneously being revealed that need to be incorporated into existing theory. These include pathogen-driven selection for antigen-binding breadth and expansion of the MHC gene family, associated autoimmunity trade-offs, hitchhiking of deleterious mutations linked to the MHC, geographic subdivision, and adaptive introgression. © 2020 The Authors
- Record ID
- UAMbceeb19fef9a4c29a5fa048a00208e75
- Author
- Journal series
- Trends in Genetics, ISSN 0168-9525, e-ISSN 1362-4555
- Issue year
- 2020
- Vol
- 36
- No
- 4
- Pages
- 298-311
- Keywords in English
- balancing selection; heterozygote advantage; major histocompatibility complex; MHC–KIR interaction; negative frequency-dependent selection; polymorphism; amino acid; glycoprotein, antigen binding; antigen presentation; balancing selection; DNA polymorphism; gene locus; gene mutation; gene structure; genealogy; human; immune response; major histocompatibility complex; multigene family; nonhuman; parasite; priority journal; Review
- ASJC Classification
- DOI
- DOI:10.1016/j.tig.2020.01.008 Opening in a new tab
- URL
- https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079066991&doi=10.1016%2fj.tig.2020.01.008&partnerID=40&md5=9efa45fcf48c7d4b81acef7d515758e8 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 200
- Score source
- journalList
- Score
- = 200.0, 07-03-2022, ArticleFromJournal
- Publication indicators
- = 59; : 2016 = 2.158; : 2019 (2 years) = 11.333 - 2019 (5 years) =11.641
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMbceeb19fef9a4c29a5fa048a00208e75/
- URN
urn:amu-prod:UAMbceeb19fef9a4c29a5fa048a00208e75
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.