Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatin
Authors:
- Tina P. Andrejević,
- Beata Irena Warżajtis,
- Biljana Đ. Glišić,
- Sandra Vojnovic,
- Marija Mojicevic,
- Nevena Lj Stevanović,
- Jasmina Nikodinovic-Runic,
- Urszula Rychlewska,
- Miloš I. Djuran
Abstract
Three novel Zn(II) complexes, [ZnCl2(qz)2] (1), [ZnCl2(1,5-naph)]n (2) and [ZnCl2(4,7-phen)2] (3), where qz is quinazoline, 1,5-naph is 1,5-naphthyridine and 4,7-phen is 4,7-phenanthroline, were synthesized by the reactions of ZnCl2 and the corresponding N-heterocyclic ligand in 1:2 molar ratio in ethanol at ambient temperature. The characterization of these complexes was done by NMR, IR and UV–Vis spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction analysis. Complexes 1 and 3 are mononuclear species, in which Zn(II) ion is tetrahedrally coordinated by two nitrogen atoms belonging to two qz or 4,7-phen ligands, respectively, and by two chloride anions, while complex 2 is a 1D coordination polymer that contains 1,5-naph as bridging ligand between two metal ions. In agar disc-diffusion assay, complexes 1–3 manifested good inhibitory activity against two investigated Candida strains (C. albicans and C. parapsilosis), while not inducing toxic effects on the healthy human fibroblast cell line (MRC-5). This activity was not fungicidal, as revealed by the broth microdilution assay, however complex 3 showed the ability to modulate Candida hyphae formation, which is an important process during infection and showed significant synergistic effect with clinically used antifungal polyene nystatin. © 2020 Elsevier Inc.
- Record ID
- UAMc854b9a96bbe4cd9af826c3f24439530
- Author
- Journal series
- Journal of Inorganic Biochemistry, ISSN 0162-0134, e-ISSN 1873-3344
- Issue year
- 2020
- Vol
- 208
- Pages
- 1-11
- Article number
- 111089
- Keywords in English
- Anti-Candida activity; Cytotoxicity; Filamentation inhibition; N-heterocycles; Synergy; Zinc(II) complexes; alcohol; antibiotic agent; antifungal agent; coordination compound; cytotoxic agent; naphthyridine derivative; nystatin; phenanthroline derivative; quinazoline derivative; zinc complex, A-549 cell line; antibacterial activity; antifungal activity; antiproliferative activity; Article; atom; broth dilution; Candida albicans; Candida parapsilosis; carbon nuclear magnetic resonance; complex formation; controlled study; crystal structure; disk diffusion; drug cytotoxicity; drug efficacy; drug mechanism; drug potentiation; drug stability; drug synthesis; embryo; environmental temperature; fungus hyphae; human; human cell; IC50; in vitro study; infrared spectroscopy; ligand binding; minimum inhibitory concentration; MRC-5 cell line; nonhuman; proton nuclear magnetic resonance; reaction analysis; structure activity relation; synergistic effect; ultraviolet visible spectroscopy; X ray crystallography; X ray diffraction
- Keywords in original language
- Zinc(II) complexes N-heterocycles Anti-Candidaactivity Filamentation inhibition Cytotoxicity Synergy
- ASJC Classification
- ;
- DOI
- DOI:10.1016/j.jinorgbio.2020.111089 Opening in a new tab
- URL
- https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084855564&doi=10.1016%2fj.jinorgbio.2020.111089&partnerID=40&md5=48651e8abf0c4a7e678fd462bf62180e Opening in a new tab
- Language
- (en) English
- License
- Score (nominal)
- 100
- Score source
- journalList
- Score
- = 100.0, 18-05-2022, ArticleFromJournal
- Publication indicators
- = 4; : 2018 = 0.895; : 2019 (2 years) = 3.212 - 2019 (5 years) =3.226
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMc854b9a96bbe4cd9af826c3f24439530/
- URN
urn:amu-prod:UAMc854b9a96bbe4cd9af826c3f24439530
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