The role of adipocytokines in the pathogenesis of knee joint osteoarthritis
Authors:
- Magdalena Richter,
- Tomasz Trzeciak,
- Maciej Owecki,
- Andrzej Pucher,
- Jacek Kaczmarczyk
Abstract
Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.
- Record ID
- UAMccffaaf5091c40708ccb51beb0659970
- Author
- Journal series
- International Orthopaedics, ISSN 0341-2695
- Issue year
- 2015
- Vol
- 39
- Pages
- 1211-1217
- ASJC Classification
- DOI
- DOI:10.1007/s00264-015-2707-9 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 30
- Score source
- journalList
- Score
- Publication indicators
- = 27; = 31; : 2015 = 1.421; : 2015 (2 years) = 2.387 - 2015 (5 years) =2.481
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMccffaaf5091c40708ccb51beb0659970/
- URN
urn:amu-prod:UAMccffaaf5091c40708ccb51beb0659970
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.