New protocol for one-pot synthesis of functionalized symmetrical 1,4-dialkyl- or 1,4-diaryl-1,3-diynes

Authors:

• Monika Rzonsowska,
• Beata Dudziec,
• Ireneusz Kownacki,
• Bogdan Marciniec

Abstract

A new versatile one-pot protocol for preparation of functionalized 1,4-disubstituted-1,3-diynes via a highly selective catalytic silylative coupling of vinylsilanes and terminal alkynes occurring via [Ru] catalyzed reaction and/or [Ir] catalyzed reaction of iodosilanes with alkynes followed by desilylative homocoupling sequence is presented. Contrary to existing stoichiometric systems, the catalytic conditions for the copper salt mediated homocoupling of trimethylsilylalkyne were elaborated that are very tolerant to various functional groups.