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Multi-gram synthesis of a hyaluronic acid subunit and synthesis of fully protected oligomers
Authors:
- Mickaël Virlouvet,
- Michael Gartner,
- Katarzyna Koroniak-Szejn,
- Jonathan P. Sleeman,
- Stefan Bräse
Abstract
Fully protected tetra-, hexa- and octasaccharides of hyaluronic acid were synthesized on a scale of several 100 mg up to gram quantities using allyl (methyl 2-O-benzoyl-3-O-benzyl-4-O-levulinoyl-β-D-glucopyranosyluronate)- (1→3)-4-O-acetyl-6-O-benzyl-2-deoxy-2-trichloroacetamido-β-D- glucopyranoside as a key building block. This disaccharide was subjected to deprotection, then glycosylation via the trichloroacetimidate method was employed to achieve the formation of the oligosaccharides. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Record ID
- UAMd37541371de34ba2a90dd06933b06abc
- Author
- Journal series
- Advanced Synthesis & Catalysis, ISSN 1615-4150
- Issue year
- 2010
- Vol
- 352
- Pages
- 2657-2662
- ASJC Classification
- ;
- DOI
- DOI:10.1002/adsc.201000008 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 0
- Score source
- journalList
- Publication indicators
- = 11; = 13; : 2010 = 1.123; : 2010 (2 years) = 5.250 - 2010 (5 years) =5.360
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMd37541371de34ba2a90dd06933b06abc/
- URN
urn:amu-prod:UAMd37541371de34ba2a90dd06933b06abc
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.