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Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners
Authors:
- Natalia Skrzypczak,
- Piotr Przybylski
- Record ID
- UAMec8e9480779f4bb8822c1c6ad550d411
- Publication categories
- Author
- Journal series
- Natural Product Reports, ISSN 0265-0568, e-ISSN 1460-4752
- Issue year
- 2022
- ASJC Classification
- ; ;
- Abstract in original language
- The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure–activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
- DOI
- DOI:10.1039/d2np00004k Opening in a new tab
- URL
- https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00004K Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 0
- Publication indicators
- : 2017 = 3.125; : 2019 (2 years) = 12.000 - 2019 (5 years) =11.666
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- Uniform Resource Identifier
- https://researchportal.amu.edu.pl/info/article/UAMec8e9480779f4bb8822c1c6ad550d411/
- URN
urn:amu-prod:UAMec8e9480779f4bb8822c1c6ad550d411
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.