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Studying the effects of cosmetic froms on the bioavailability of carotenoids selected

Joanna Igielska-Kalwat

Abstract

The skin makes a very good model for investigation of the phenomenon of ageing. It is exposed to the destructive influence of external factors and its ageing is faster than that of the other parts of human body. The thesis begins with a survey of literature on ageing and cosmetic chemistry. The structure of skin. The second chapter of the thesis concerns a special group of antioxidants that is carotenoids. The methods for in vivo investigation of cosmetic formulations (tests on probands), for evaluation of stability of cosmetic formulations and determination of the composition of cosmetic formulations are described along with the methods for evaluation of bioavailability with the use of stripping and kinetics of active ingredient release from cosmetic formulations. The aim of the experimental part was to design and synthesise cosmetic formulations of antioxidating effect based on carotenoids as the active ingredients. Within the doctoral dissertation a new cosmetic formulation with beta carotenoid as an antioxidant was designed, obtained and tested in vivo on a group of probands. The application tests confirmed improvement in skin moisturising, elasticity and oiling of the skin of the probands. The cosmetic product designed and proposed was shown to improve the general condition of the skin. The study of beta-carotenoid bioavailability by the method of stripping proved that this carotenoid penetrates to the upper layer of epidermis, stratum corneum. The results contribute to development of cosmetic chemistry, a new interdisciplinary branch of research combining chemistry, analytical chemistry and biotechnology. The results of the experiment have brought new information needed for design and characterisation of cosmetic products containing carotenoids.
Record ID
UAM22206fda0d964023a3097e9c32468e10
Diploma type
Doctor of Philosophy
Author
Joanna Igielska-Kalwat (SNŚ/WC/FoC) Joanna Igielska-Kalwat,,
Title in Polish
Badanie wpływu form kosmetycznych na biodostępność wybranych karotenoidów
Title in English
Studying the effects of cosmetic froms on the bioavailability of carotenoids selected
Language
pl Polish
Certifying Unit
Faculty of Chemistry (SNŚ/WC/FoC)
Discipline
chemistry / (chemical sciences domain) / (physical sciences)
Scientific discipline (2.0)
6.5 chemical sciences
Defense Date
14-03-2016
End date
14-03-2016
Supervisor
URL
http://hdl.handle.net/10593/14415 opening in a new tab
Keywords in English
carotenoids, bioavailability, in vivo studies
Abstract in English
The skin makes a very good model for investigation of the phenomenon of ageing. It is exposed to the destructive influence of external factors and its ageing is faster than that of the other parts of human body. The thesis begins with a survey of literature on ageing and cosmetic chemistry. The structure of skin. The second chapter of the thesis concerns a special group of antioxidants that is carotenoids. The methods for in vivo investigation of cosmetic formulations (tests on probands), for evaluation of stability of cosmetic formulations and determination of the composition of cosmetic formulations are described along with the methods for evaluation of bioavailability with the use of stripping and kinetics of active ingredient release from cosmetic formulations. The aim of the experimental part was to design and synthesise cosmetic formulations of antioxidating effect based on carotenoids as the active ingredients. Within the doctoral dissertation a new cosmetic formulation with beta carotenoid as an antioxidant was designed, obtained and tested in vivo on a group of probands. The application tests confirmed improvement in skin moisturising, elasticity and oiling of the skin of the probands. The cosmetic product designed and proposed was shown to improve the general condition of the skin. The study of beta-carotenoid bioavailability by the method of stripping proved that this carotenoid penetrates to the upper layer of epidermis, stratum corneum. The results contribute to development of cosmetic chemistry, a new interdisciplinary branch of research combining chemistry, analytical chemistry and biotechnology. The results of the experiment have brought new information needed for design and characterisation of cosmetic products containing carotenoids.
Thesis file

Uniform Resource Identifier
https://researchportal.amu.edu.pl/info/phd/UAM22206fda0d964023a3097e9c32468e10/

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