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Funkcjonalne retrogeny w genomie człowieka (Functional retrogenes in human genome)

Joanna Ciomborowska-Basheer

Abstract

Retrogenes are gene copies generated via reverse transcription of mRNA and incorporation of created cDNA into genomic sequence. This process is called retroposition and as a result we can observe that multi-exonic parental gene gives birth to single-exon retrocopy. The main goal of this PhD project was to analyse the retroposition in the human genome focusing on accompanying evolutionary phenomenon, such as intron gain and replacement of parental genes by retrogenes. Presented analysis led us to discovery and characterization of these processes. Research related to presented PhD project helped to understand the human genome better, which despite of the end of sequencing project and many years of analyses, still has many secrets. Our and other research of „junk DNA” show that retrosequences may be important, functional and even crucial in many processes.
Record ID
UAM32ab481eca6249d697bfdb992424aeb8
Diploma type
Doctor of Philosophy
Author
Title in Polish
Funkcjonalne retrogeny w genomie człowieka (Functional retrogenes in human genome)
Language
pol (pl) Polish
Certifying Unit
Faculty of Biology (SNP/WB/FoB) [Not active]
Discipline
biology / (biological sciences domain) / (biological sciences)
Status
Finished
Year of creation
2014
Start date
24-05-2013
Defense Date
19-05-2014
Title date
23-05-2014
Supervisor
Honored
yes
Keywords in English
Evolutionary genomics
Abstract in English
Retrogenes are gene copies generated via reverse transcription of mRNA and incorporation of created cDNA into genomic sequence. This process is called retroposition and as a result we can observe that multi-exonic parental gene gives birth to single-exon retrocopy. The main goal of this PhD project was to analyse the retroposition in the human genome focusing on accompanying evolutionary phenomenon, such as intron gain and replacement of parental genes by retrogenes. Presented analysis led us to discovery and characterization of these processes. Research related to presented PhD project helped to understand the human genome better, which despite of the end of sequencing project and many years of analyses, still has many secrets. Our and other research of „junk DNA” show that retrosequences may be important, functional and even crucial in many processes.
Thesis file
  • File: 1
    rozprawa_doktorska_J.Ciomborowska_2014.pdf
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Citation count
6

Uniform Resource Identifier
https://researchportal.amu.edu.pl/info/phd/UAM32ab481eca6249d697bfdb992424aeb8/
URN
urn:amu-prod:UAM32ab481eca6249d697bfdb992424aeb8

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