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## Structural changes in the brain and the clinical image of neuropsychological functions in men with alcohol use disorders

### Natalia Nowaczyk

#### Abstract

The most important goals of the research were: (1) to verify the strength and direction of the relationships between alcohol consumption rate, structural changes to the brain, and the clinical image of neuropsychological functions; (2) to evaluate temperament structure as a moderator of the relationship between structural changes to the brain and the efficiency of dynamic praxia and cognitive and executive functions; (3) to verify the neuropsychological model of alcohol-induced brain changes, while comparing the specific profile of pathological and nonpathological brain changes resulting from alcohol use disorder. The screening, neuroimaging (by using 1.5T and 3T MRI), and neuropsychological examination (extended to measure temperament structure) included 103 men with alcohol use disorder. Among other things, the examination tested two main models of neuropsychological structural changes to the brain in alcohol use disorder, based on the main assumptions of Jason W. Brown’s microgenetic theory. Among men with alcohol use disorder with a nonharmonized temperament structure a stronger association was observed between brain atrophy and impaired memory and learning. Moreover, one-third of the examined men were characterized by neuropsychological disorders, pathological changes in the frontal lobes and the ventricular system, longer alcohol abuse history, and greater daily alcohol use. These results should contribute to the development of dependence neuropsychology, especially in the areas of diagnosis and treatment.
Record ID
UAM8b36312cd4bf4e2cb479453a01183017
Diploma type
Doctor of Philosophy
Author
Title in Polish
Zmiany strukturalne mózgu a obraz kliniczny funkcji neuropsychologicznych u mężczyzn z zaburzeniem używania alkoholu
Title in English
Structural changes in the brain and the clinical image of neuropsychological functions in men with alcohol use disorders
Language
pol (pl) Polish
Certifying Unit
Wydział Psychologii i Kognitywistyki [nowa struktura organizacyjna] (SNs/WPiK)
Scientific discipline (2.0)
5.11 psychology
Status
Finished
Year of creation
2021
Defense Date
20-09-2021
Title date
20-09-2021
Supervisor
Pages
299
URL
https://hdl.handle.net/10593/26434 Opening in a new tab
Keywords in English
alcohol use disorder; brain structural changes; neuropsychological functions; temperament structure
Abstract in English
The most important goals of the research were: (1) to verify the strength and direction of the relationships between alcohol consumption rate, structural changes to the brain, and the clinical image of neuropsychological functions; (2) to evaluate temperament structure as a moderator of the relationship between structural changes to the brain and the efficiency of dynamic praxia and cognitive and executive functions; (3) to verify the neuropsychological model of alcohol-induced brain changes, while comparing the specific profile of pathological and nonpathological brain changes resulting from alcohol use disorder. The screening, neuroimaging (by using 1.5T and 3T MRI), and neuropsychological examination (extended to measure temperament structure) included 103 men with alcohol use disorder. Among other things, the examination tested two main models of neuropsychological structural changes to the brain in alcohol use disorder, based on the main assumptions of Jason W. Brown’s microgenetic theory. Among men with alcohol use disorder with a nonharmonized temperament structure a stronger association was observed between brain atrophy and impaired memory and learning. Moreover, one-third of the examined men were characterized by neuropsychological disorders, pathological changes in the frontal lobes and the ventricular system, longer alcohol abuse history, and greater daily alcohol use. These results should contribute to the development of dependence neuropsychology, especially in the areas of diagnosis and treatment.

Uniform Resource Identifier
https://researchportal.amu.edu.pl/info/phd/UAM8b36312cd4bf4e2cb479453a01183017/
URN
urn:amu-prod:UAM8b36312cd4bf4e2cb479453a01183017

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