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Pressure-induced structural transformation of carbohydrate crystals

Ewa Maria Patyk-Kaźmierczak

Abstract

The aim of this PhD thesis was to describe the high-pressure behaviour of several carbohydrates and their intermolecular interactions in order to learn more about their crystals formation and stability. High-pressure diffraction studies of α-D-glucose and β-D-mannose revealed their new polymorphs, while the α-D-mannose ambient pressure phase has proven to be exceptionally resistant to the pressure up to 10 GPa. All crystal structures were analysed in respect of molecular conformation, voids distributions, and H-bonding pattern arrangements, in order to designate similarities and explain the differences in their pressure behaviour. Moreover the ribose polymorphs and racemate has been analysed, revealing the interplay between molecular conformation and the H-bonding patterns, and demonstrating possible application of underestimated L enantiomers for obtaining high-quality racemate crystals of otherwise hardly crystallising enantiomers. Results presented in the thesis, and enclosed publications, contribute to better understanding of the crystallisation process of one of the most important group of organic compounds and broadens our knowledge about some of the most frequent types of the cohesion forces: OH∙∙∙O and CH∙∙∙O hydrogen bonds. It also gives an insight into the influence of molecular shape and conformation on crystal stability.
Record ID
UAMbfc91fc695494213870d3593b9b41cf0
Diploma type
Doctor of Philosophy
Author
Ewa Maria Patyk-Kaźmierczak (DoMC) Ewa Maria Patyk-Kaźmierczak,,
Title in Polish
Wysokociśnieniowe przemiany strukturalne kryształów węglowodanów
Title in English
Pressure-induced structural transformation of carbohydrate crystals
Language
pl Polish
Certifying Unit
Faculty of Chemistry (SNŚ/WC/FoC)
Discipline
chemistry / (chemical sciences domain) / (physical sciences)
Scientific discipline (2.0)
6.5 chemical sciences
Defense Date
05-10-2016
Title date
05-10-2016
Supervisor
URL
http://hdl.handle.net/10593/14949 opening in a new tab
Keywords in English
carbohydrates, hydrogen bonds, high pressure, crystal structures, polymorphism
Abstract in English
The aim of this PhD thesis was to describe the high-pressure behaviour of several carbohydrates and their intermolecular interactions in order to learn more about their crystals formation and stability. High-pressure diffraction studies of α-D-glucose and β-D-mannose revealed their new polymorphs, while the α-D-mannose ambient pressure phase has proven to be exceptionally resistant to the pressure up to 10 GPa. All crystal structures were analysed in respect of molecular conformation, voids distributions, and H-bonding pattern arrangements, in order to designate similarities and explain the differences in their pressure behaviour. Moreover the ribose polymorphs and racemate has been analysed, revealing the interplay between molecular conformation and the H-bonding patterns, and demonstrating possible application of underestimated L enantiomers for obtaining high-quality racemate crystals of otherwise hardly crystallising enantiomers. Results presented in the thesis, and enclosed publications, contribute to better understanding of the crystallisation process of one of the most important group of organic compounds and broadens our knowledge about some of the most frequent types of the cohesion forces: OH∙∙∙O and CH∙∙∙O hydrogen bonds. It also gives an insight into the influence of molecular shape and conformation on crystal stability.

Uniform Resource Identifier
https://researchportal.amu.edu.pl/info/phd/UAMbfc91fc695494213870d3593b9b41cf0/

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